Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models

Since half of the genes are inherited from paternal side, maternal immune system has to tolerate presence foreign antigens. Regulatory T cells facilitate development and maintenance peripheral tissue tolerance fetus during pregnancy. Reduction in regulatory is associated with complications pregnancy, including spontaneous abortion. Recent studies mouse models have shown that adoptive transfer Tregs can prevent abortion through improving tolerance. Thus, cell therapy using autologous could potentially be a novel therapeutic approach for cell-based immunotherapy women unexplained Besides, strategies activating expanding antigen-specific ex vivo based on pharmacological agents pave foundation an incorporating pharmacotherapy. This review aims elaborate current understanding potential treatment disease.